What CircleDNA does
CircleDNA is a Hong Kong-based company offering premium DNA test kits with whole exome sequencing. Their products range from basic health screening (~$189) to comprehensive packages ($499-$629) covering health risk, drug response, nutrition, ancestry, and cancer screening.
Key features
- Whole exome sequencing (covers all protein-coding genes)
- Premium test kits at multiple price tiers ($189-$629)
- Health risk assessment, drug response, and cancer screening
- Nutrition, fitness, and wellness reports
- Ancestry and family planning reports
- One-time genetic counselor consultation included with premium tiers
Health analysis: how they differ
CircleDNA requires purchasing their own test kit — no raw data uploads from other providers. Premium pricing means the comprehensive package costs significantly more than using existing data with an interpretation service. They don't accept 23andMe or AncestryDNA raw data files.
Your DNA Unlocked takes a different approach: transparent clinical databases (ClinVar with 341,000+ classified variants, PharmGKB for drug-gene interactions), detailed pharmacogenomics (CYP2D6, CYP2C19, CYP2C9, CYP3A4, CYP1A2), methylation pathway analysis (MTHFR, COMT, MTRR), and a structured health protocol with specific recommendations.
The bottom line
CircleDNA offers a premium testing experience with whole exome sequencing. If you already have raw data from 23andMe or AncestryDNA, Your DNA Unlocked gives you comprehensive health analysis from your existing data without needing a new (expensive) test.
Who should use which
Choose CircleDNA if:
- You haven't taken a DNA test yet and want whole exome sequencing
- You want a premium testing experience with genetic counseling included
- You're willing to pay more for a comprehensive initial test package
Choose Your DNA Unlocked if:
- You already have raw DNA data and want deep health analysis
- You want detailed pharmacogenomics (how your genes affect medication response)
- You want comprehensive disease risk screening against ClinVar
- You want an actionable health protocol with supplement, diet, and monitoring guidance
Frequently asked questions
Do I need CircleDNA to use Your DNA Unlocked?
No. Your DNA Unlocked accepts raw data from 23andMe, AncestryDNA, and other major testing companies. You need a raw data file from some provider, but it doesn't have to be CircleDNA.
Can I use both?
In many cases, yes. If CircleDNA generates raw data you can download, you can upload it to Your DNA Unlocked for additional health analysis. The services can complement each other.
What if I already have data from a different company?
Your DNA Unlocked works with raw data from 23andMe, AncestryDNA, and other major providers. You don't need to switch to or buy from CircleDNA.