What Promethease does
Promethease is a literature retrieval tool that cross-references your raw DNA data against SNPedia, a wiki-style database of genetic research. You upload your raw data and get a report linking each variant to published research. It was acquired by MyHeritage in 2019 and made free to use.
Key features
- Cross-references raw data against SNPedia (a wiki of genetic research)
- Free to use (after MyHeritage acquisition)
- Covers a wide range of traits, conditions, and drug responses
- Links directly to published research for each variant
- Community-maintained database with frequent updates
Health analysis: how they differ
Promethease gives you a large, unsorted dump of genetic associations. There's no prioritization, no actionable protocol, and no clear distinction between well-established pathogenic variants and speculative research associations. It requires significant genetics knowledge to interpret. The output can be overwhelming — hundreds of entries with varying levels of evidence quality.
Your DNA Unlocked takes a different approach: transparent clinical databases (ClinVar with 341,000+ classified variants, PharmGKB for drug-gene interactions), detailed pharmacogenomics (CYP2D6, CYP2C19, CYP2C9, CYP3A4, CYP1A2), methylation pathway analysis (MTHFR, COMT, MTRR), and a structured health protocol with specific recommendations.
Promethease is the closest thing to a search engine for your DNA. It's powerful if you know what you're looking for, but it doesn't help you figure out what matters. Your DNA Unlocked does the prioritization and interpretation work that Promethease leaves to you.
Who should use which
Choose Promethease if:
- You have a strong genetics background and want raw research links
- You want a free tool for exploring your SNP data
- You enjoy digging through scientific literature yourself
Choose Your DNA Unlocked if:
- You already have raw DNA data and want deep health analysis
- You want detailed pharmacogenomics (how your genes affect medication response)
- You want comprehensive disease risk screening against ClinVar
- You want an actionable health protocol with supplement, diet, and monitoring guidance
Can you use both?
Yes. Many users start with a testing company like Promethease for the initial test and ancestry results, then download their raw data and upload it to Your DNA Unlocked for comprehensive health analysis. The two services complement each other.
Frequently asked questions
Do I need Promethease to use Your DNA Unlocked?
No. Your DNA Unlocked accepts raw data from 23andMe, AncestryDNA, and other major testing companies. You need a raw data file from some provider, but it doesn't have to be Promethease.
Is one more accurate than the other?
They serve different purposes. Promethease is a testing/interpretation service. Your DNA Unlocked is a health interpretation service. Accuracy depends on what you're measuring — ancestry accuracy and health analysis accuracy are different things evaluated by different standards.
What if I already have Promethease data?
Download your raw data file from your Promethease account and upload it to Your DNA Unlocked. You'll get comprehensive health reports without needing to take another test.